What is Prostaglandin Analogs (PGAs)? - Glaucoma Glossary

Prostaglandin analogs are a class of synthetic lipid compounds used universally as first-line topical medical therapy to significantly increase uveoscleral outflow of aqueous humor.

What it means for the patient

These are the most commonly prescribed once-daily eye drops for glaucoma (like Latanoprost or Lumigan). They are highly effective, requiring just one drop at bedtime to help fluid exit the eye more freely.

Clinical significance

PGAs are the cornerstone of medical glaucoma management, typically yielding a 25-30% reduction in IOP. They are favored for systemic safety, high efficacy, and convenience, though ocular surface side effects like hyperemia exist.

How it is tracked

Commencement and cessation of PGA regimens are mapped in Glaucoma One, letting clinicians align medication compliance dates with corresponding IOP troughs.